$450 mil? I couldn't blow through that in a lifetime. But I know where I'd start
I'd build a house for everyone in my family, including myself. Mine would have a library in it, just because that's something I've always wanted, and I would buy any book I wanted whenever I wanted.
While construction was underway I would take us all on vacation. We'd make a world tour, hitting all the places we've always wanted to go: the British Isles, the Alps, Australia, New Zealand, Tahiti, Thailand, and wherever else we decided to go.
After that it would be pretty boring, though. I'd settle in with my house and my books. But I think I'd also spend a lot of my time doing all the volunteer work I wish I could do, but can't because I'm too busy working. I'd probably donate a lot of it, because once the essentials are met (I've got a house and enough to live on) I don't need millions just sitting in the bank.